SF20/MYDGF Products

Description

Myeloid-Derived Growth Factor, or MYDGF, is a Bone marrow-derived monocyte protein, and it is correlated with enhanced metabolic activity, suppression of apoptosis, and stimulation of cell proliferation (1). MYDGF is expressed predominantly in inflammatory cells, such as monocytes and macrophages (1). Up-regulation of MYDGF expression was also found during adipocyte differentiation (2). Expression of MYDGF was induced in the circulation and heart tissue after myocardial infarction. It promotes cardiac myocyte survival by stimulating endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway, and inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (1). MYDGF was found over-expressed in approximately two-thirds of Hepatocellular Carcinoma (HCC) tissues, and its expression was significantly positively correlated with that of alpha-fetoprotein (AFP) (3). In HCC, MYDGF could regulate cell proliferation through activating Akt/mitogen-activated protein kinase pathways (3). Mouse MYDGF shares 92% amino acid sequence identity with both human and rat MYDGF. Intriguingly, virtually all homologs of MYDGF have a C-terminal putative ER retention sequence BXEL (B: Arg, His, or Lys; X: variable residue; E: Glu; L: Leu), which has the potential to retain human MYDGF and its homologs in the ER, whereas truncated MYDGF without BXEL is secreted from the cell (4). However, the functions of these different forms remain unclear.

Bioinformatics

Entrez	140806 Mouse 501996 Rat 56005 Human
Uniprot	AAH10129 Human NP_061980 Human NP_061980.1 Human Q969H8 Human
Product By Gene ID	56005
Alternate Names	C19orf10 chromosome 19 open reading frame 10 EUROIMAGE1875335 IL25 IL27 IL27w interleukin 27 working designation interleukin-25 Ly6elg MYDGF myeloid-derived growth factor R33729_1 SF20 Stromal cell-derived growth factor SF20 UPF0556 protein C19orf10

Research Areas for SF20/MYDGF

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Biologically Active Proteins