SEC22B Products

Description

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. FUNCTION: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. SUBUNIT: Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Bioinformatics

Entrez	9554 Human 20333 Mouse 310710 Rat
Uniprot	O75396 Human
Product By Gene ID	9554
Alternate Names	ERS24 ERS-24sec22b SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) SEC22 vesicle trafficking protein homolog B (S. cerevisiae) SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) SEC22 vesicle trafficking protein-like 1 SEC22 vesicle-trafficking protein homolog B SEC22 vesicle-trafficking protein-like 1 SEC22, vesicle trafficking protein (S. cerevisiae)-like 1 SEC22L1ER-Golgi SNARE of 24 kDa vesicle-trafficking protein SEC22b