SCAMP2 Products

Description

Secretory carrier membrane proteins (SCAMPs) are proteins that are components of post-Golgi membranes. These proteins are implicated to function in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments that are involved in the recycling of cell surface receptors and endocytosis. In neurons, SCAMPs are associated with synaptic vesicles, secretion granules and transporter vesicles. SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1-3 contain cytoplasmic N-terminal regions with NPF repeats. NPF repeats are found to interact with EH domain proteins that function in budding of transport vesicles from the plasma membrane or the Golgi complex. SCAMPs 4 and 5 lack the N-terminal NPF repeats. SCAMPs 1-4 are all ubiquitously coexpressed while SCAMP 5 is only detectable in the brain. Studies show that SCAMP 5 is expressed late in development which is coincident with expansion of mature synapses.

Bioinformatics

Entrez	10066 Human 24044 Mouse
Uniprot	AAH01376 Human NM_005697 Human
Product By Gene ID	10066
Alternate Names	secretory carrier membrane protein 2secretory carrier-associated membrane protein 2

Diseases related to SCAMP2

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Anxiety Disorders
Depressive Symptom
Liver Carcinoma
Insulinoma
Vertigo
Cholera
Bartter Disease
Depressive Disorder
Kidney Diseases
Inflammation
Salmonella Infections
Platelet Storage Pool Deficiency

Pathways for SCAMP2

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Transport
Exocytosis
Localization
Membrane Fusion
Secretion
Secretory Pathway
Endocytosis
Insulin Secretion
Abscission
Dopamine Uptake
Cytokinesis
Telophase
Translation
Cell Growth
Wound Healing
Hemostasis

Research Areas for SCAMP2

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Membrane Trafficking and Chaperones

PTMs for SCAMP2

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Phosphorylation
Cleavage
Myristoylation

Bioinformatics Tool for SCAMP2

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