SARS-CoV-2 Nucleocapsid Products

Antibodies
SARS-CoV-2 Nucleocapsid Antib ...
SARS-CoV-2 Nucleocapsid Antibody (...
NBP3-00514
Species: V, V
Applications: WB, ELISA, ELISA(Det), LFA
Host: Mouse Monoclonal
SARS-CoV-2 Nucleocapsid Antib ...
SARS-CoV-2 Nucleocapsid Antibody
NBP3-00510
Species: V, V-Vi
Applications: WB, Simple Western
Host: Rabbit Polyclonal
SARS-CoV-2 Nucleocapsid Antib ...
SARS-CoV-2 Nucleocapsid Antibody
NBP3-05730
Species: V
Applications: WB, ELISA, Flow, ICC/IF, IHC, IP
Host: Rabbit Monoclonal
ELISA Kits
SARS-CoV-2 Nucleocapsid ELISA ...
SARS-CoV-2 Nucleocapsid ELISA Kit ...
NBP3-11405
Applications: ELISA, S-ELISA
Proteins
Recombinant SARS-CoV-2 Nucleo ...
Recombinant SARS-CoV-2 Nucleocapsi...
NBP2-90975
Recombinant SARS-CoV-2 Nucleo ...
Recombinant SARS-CoV-2 Nucleocapsi...
NBP3-07085
Applications: Func
Recombinant SARS-CoV-2 Nucleo ...
Recombinant SARS-CoV-2 Nucleocapsi...
NBP3-07086
Applications: Func

Description

The SARS-CoV-2 Nucleocapsid protein is one of the four major structural proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 (1,2). The nucleocapsid protein is an RNA-binding protein that is essential for viral assembly into a ribonucleoprotein complex and also functions in viral budding (2,3). More specifically, after viral replication and RNA synthesis, the viral genomes that are encapsulated by the nucleocapsid protein will bud into the membrane and help with mature virus formation (2). The nucleocapsid protein is synthesized as 419 amino acids (aa) in length with a theoretical molecular weight of 45.6 kDa (4). Structurally, the nucleocapsid protein contains an RNA-binding domain (N1b), a dimerization domain (N2b), and a few shorter regions (N1a, N2a, and spacer B/N3) (3). It is the N1b domain that is suggested to be involved in RNA binding (3). The nucleocapsid N1b domain contains a beta-hairpin, a loop region, and a beta-sheet core, giving it a right-handed shape (3). Conversely, the N2b domain functions in dimerization which promotes assembly into a helical filament where the dimer interface is made of two beta-strands and an alpha-helix portion (3). Inhibition of nucleocapsid assembly may be a potential target for treating COVID-19 infection.

Following SARS-CoV-2 infection, B cells and T cells display an immune response against nucleocapsid protein and nucleocapsid-specific neutralizing antibodies are produced (5). Interestingly, a study of patients who have recovered from COVID-19 revealed that there were no neutralizing antibodies against nucleocapsid protein present; however, a high presence against neutralizing spike RBD antibodies were detected (5).

References

1. Pillay T. S. (2020). Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. Journal of Clinical Pathology. https://doi.org/10.1136/jclinpath-2020-206658

2. Malik Y. A. (2020). Properties of Coronavirus and SARS-CoV-2. The Malaysian Journal of Pathology.

3. Zhu, G., Zhu, C., Zhu, Y., & Sun, F. (2020). Minireview of progress in the structural study of SARS-CoV-2 proteins. Current Research in Microbial Sciences. https://doi.org/10.1016/j.crmicr.2020.06.003

4. Uniprot (P0DTC9)

5. Shah, V. K., Firmal, P., Alam, A., Ganguly, D., & Chattopadhyay, S. (2020). Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.01949

Bioinformatics

Product By Gene ID 43740575
Alternate Names
  • nucleocapsid phosphoprotein
  • ORF9; structural protein
  • SARS-CoV-2
  • COVID-19 nucleocapsid protein
  • SARS-CoV-2 N protein
  • SARSCoV2 Nucleoprotein
  • SARS-CoV-2 Nucleocapsid protein
  • 2019-nCoV Nucleocapsid Protein
  • Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein
  • Nucleoprotein
  • Human coronavirus Nucleoprotein
  • 2019-nCoV N Protein
  • Nucleocapsid protein
  • COVID-19 N protein

Bioinformatics Tool for SARS-CoV-2 Nucleocapsid

Discover related pathways, diseases and genes to SARS-CoV-2 Nucleocapsid. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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