SARS-CoV-2 Nucleocapsid Products


Description

Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). Seven coronaviruses had been found to cause human infection including SARS-CoV-2/2019-nCoV resulting in a potentially fatal atypical pneumonia, named COVID-19. SARS-CoV-2 has 4 major structural proteins including spike (S), envelope (E), membrane (M), and nucleocapsid (N), which share significant sequence homology with SARS-CoV. The most prominent protein in the culture supernatants infected with SARS virus is the 46 kDa nucleocapsid protein. SARS-CoV-2 nucleocapsid protein is critical for packaging the viral genome via protein oligomerization. Additionally, the SARS-CoV nucleocapsid protein has been implicated in other functions such as the modulation of host cellular processes including cell cycle deregulation, inhibition of IFN production, and induction of proinflammatory factors (e.g. COX-2).

Bioinformatics

Alternate Names
  • COVID-19 nucleocapsid protein
  • SARS-CoV-2 N protein
  • SARSCoV2 Nucleoprotein
  • SARS-CoV-2 Nucleocapsid protein
  • 2019-nCoV Nucleocapsid Protein
  • Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein
  • Nucleoprotein
  • Human coronavirus Nucleoprotein
  • 2019-nCoV N Protein
  • Nucleocapsid protein
  • COVID-19 N protein