Rpn2 Products

Antibodies
Rpn2 Antibody
Rpn2 Antibody
NB120-2941
Species: Hu, Mu, Bv
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Rpn2 Antibody
Rpn2 Antibody
NBP2-38323
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Rpn2 Antibody
Rpn2 Antibody
NBP2-38324
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Rpn2 Overexpression Lysate (N ...
Rpn2 Overexpression Lysate (Native)
NBL1-14894
Applications: WB
Proteins
Rpn2 Recombinant Protein Anti ...
Rpn2 Recombinant Protein Antigen
NBP2-38324PEP
Species: Hu
Applications: AC
Rpn2 Recombinant Protein Anti ...
Rpn2 Recombinant Protein Antigen
NBP2-38323PEP
Species: Hu
Applications: AC
Rpn2 Recombinant Protein
Rpn2 Recombinant Protein
NBP2-23416
Species: Hu
Applications: PAGE
RNAi
Rpn2 RNAi
Rpn2 RNAi
H00005707-R01
Species: Hu

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmas's syndrome, and Liddle syndrome.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 5707
Alternate Names
  • 26S proteasome regulatory subunit S1
  • 26S proteasome regulatory subunit RPN2
  • MGC133041
  • S1
  • MGC133040
  • Rpn2
  • 26S proteasome non-ATPase regulatory subunit 1
  • P112
  • 26S proteasome subunit p112
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Pathways for Rpn2

View related products by pathway and learn more about each of the pathways below.

Proteolysis
Reverse Transcription
Cell Cycle
Cell Death
Oxidative Phosphorylation
Protein Unfolding
Glycolysis
Conjugation

Research Areas for Rpn2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Neuroscience
Ubiquitin Proteasome Pathway

PTMs for Rpn2

Learn more about PTMs related to Rpn2.

Phosphorylation
Ubiquitination

Bioinformatics Tool for Rpn2

Discover related pathways, diseases and genes to Rpn2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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