RNF7 Products

Description

RNF7 is encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Bioinformatics

Entrez	19823 Mouse 9616 Human
Uniprot	AAH05966 Human NM_014245 Human Q9UBF6 Human
Product By Gene ID	9616
Alternate Names	CKBBP1zinc RING finger protein SAG CKII beta-binding protein 1 Rbx2 RBX2 Regulator of cullins 2 ring finger protein 7rbx2 ROC2RING-box protein 2 SAGsensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2 Sensitive to apoptosis gene protein