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RHEBL1 (Ras Homolog Enriched In Brain Like 1) is involved in mediating signal transduction and regulating NF-kappa B-mediated gene transcription. RHEBL1 is known to have interactions with MTOR, ACVR1, SMAD2, TXNL4A and EIF4EBP1. RHEBL1 has been studied in relation to tuberous sclerosis, renal clear cell carcinoma and angiomyolipoma.