RelB Products

Description

RelB, also known as I-Rel, is a member of the Rel transcription factor family which also include; RelA-p65, c-Rel, NF-kB1 p100/52 and NF-kB2 p105/50 (1). Unlike other Rel-related protein, RelB does not bind to DNA or to inhibitor IkB, but is instead sequestered in the cytoplasm by precursor p100. Once p100 is processed, the p52/RelB complex translocates into the nucleus (2). RelB is also the transcription factor that has been associated most directly with dendritic cells (DCs) differentiation and function (3). It is upregulated and translocated into the nuclei of DC in response to various stimuli. RelB is also essential for generating a specific DC subset (CD11c+/CD11b+/CD8-/Dec205-) from hematopoietic stem cells (5).

Bioinformatics

Entrez	19698 Mouse 305584 Rat 5971 Human
Uniprot	NP_006500 Human NP_006500.2 Human Q01201 Human
Product By Gene ID	5971
Alternate Names	IREL I-REL I-Rel nuclear factor of kappalight polypeptide gene enhancer in B-cells 3 v-rel reticuloendotheliosis viral oncogene homolog B

Research Areas for RelB

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Phospho-Specific

Related RelB Blog Posts

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NFkB and p62 Both Activate and Regulate Inflammation Nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) is a protein complex that regulates DNA transcription and is a critical regulator of cell survival. NFkB has long been known as a primer of inflammation, however researchers are ...    Read more.

RelA/NF-kB - A proinflammatory signaling pathway with roles in immunity and cancer The inflammatory response consists of a complex network of signaling pathways that regulate a diverse set of cytokines, growth factors, adhesion molecules, and transcription factors (1). Of the proinflammatory signaling pathways the NF-kB family is...    Read more.

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