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RDH5, also known as 11-cis retinol dehydrogenase, is a 35 kDa 318 amino acid protein located in the membrane. RDH5 is involved with the catalyzation in the last step of the biosynthesis of 11-cis retinaldehyde. Current research on RDH5 is being conducted in relation to night blindness, liver disease, adenomatous polyposis coli, cone dystrophy, and macular dystrophy. RDH5 is linked to the vitellogenesis, regeneration, oocyte growth and metaphase pathways where it interacts with DGAT1, ALDH1A2, ALDH1A1, RLBP1 and RGR.
