RC74 Products

Description

Formation of the mature 3' ends of the vast majority of cellular mRNAs occurs through cleavage and polyadenylation and requires a cleavage and polyadenylation specificity factor (CPSF) containing, among other proteins, CPSF-73 and CPSF-100. RC-74 is an exclusively nuclear protein found in HeLa cells that has similar characteristics to CPSF-100. Like the complex that forms between CPSF-100 and CPSF-73, studies show that RC-74 may form a similar complex with RC-68 that is independent from the CPSF complex. This RC-68 / RC-74 complex may be involved in a pre-mRNA processing event other than cleavage and polyadenylation, such as the 3' end processing of a distinct subset of cellular pre-mRNAs encoding proteins required for G(1) progression and entry into S phase.

Bioinformatics

Entrez	55756 Human
Uniprot	Q8TB16 Human NM_018250 Human Q9NV88 Human AAH25267.1 Human
Product By Gene ID	55756
Alternate Names	Int9 RC-74 INT9 FLJ10871 RC74 CPSF2L Protein related to CPSF subunits of 74 kDa integrator complex subunit 9

Pathways for RC74

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Rna Interference

PTMs for RC74

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Cleavage

Bioinformatics Tool for RC74

Discover related pathways, diseases and genes to RC74. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.