RAPGEF5 Products

Description

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Bioinformatics

Product By Gene ID	9771
Alternate Names	GFRREPAC Guanine nucleotide exchange factor for Rap1 KIAA0277M-Ras-regulated GEF M-Ras-regulated Rap GEF MRGEF MR-GEFrap guanine nucleotide exchange factor 5 Rap guanine nucleotide exchange factor (GEF) 5 Related to Epac Repac

Research Areas for RAPGEF5

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Neuroscience