PUF60 Products

Description

PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. PUF60 also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. PUF60 gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for PUF60 gene.

Bioinformatics

Entrez	22827 Human 67959 Mouse
Uniprot	AAH09734 Human AAH11979 Human NP_055096 Human NP_055096.2 Human NP_510965 Human NP_510965.1 Human Q9UHX1 Human Q9UHX1-2 Human
Product By Gene ID	22827
Alternate Names	FBP interacting repressor FBP-interacting repressor FIRpoly-U binding splicing factor PUF60 FLJ31379 FUSE-binding protein-interacting repressor poly(U)-binding-splicing factor PUF60 poly-U binding splicing factor 60KDa Ro ribonucleoprotein binding protein 1 Ro ribonucleoprotein-binding protein 1 Ro-binding protein 1 roBP1 RoBP1 ROBPI RoBPI siah binding protein 1,60 kDa poly(U)-binding-splicing factor Siah-binding protein 1 siah-BP1 Siah-BP1 SIAHBP1pyrimidine tract binding splicing factor