Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Mycoplasma
Host: Mouse Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
5799 |
| Alternate Names |
- EC 3.1.3.48
- IA-2beta
- IAR/receptor-like protein-tyrosine phosphatase
- ICAARIARPTPRP
- Islet cell autoantigen-related protein
- KIAA0387
- phogrin
- protein tyrosine phosphatase receptor pi
- protein tyrosine phosphatase, receptor type, N polypeptide 2
- receptor-type tyrosine-protein phosphatase N2
- R-PTP-N2
- tyrosine phosphatase IA-2 beta
|
