PSMD7 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.

Bioinformatics

Entrez	5713 Human
Uniprot	AAH12606 Human
Product By Gene ID	5713
Alternate Names	26S proteasome non-ATPase regulatory subunit 7 26S proteasome regulatory subunit RPN8 Moloney leukemia virus-34 proviral integration Mov34 homolog Mov34 protein homolog MOV3426S proteasome regulatory subunit S12 MOV34L P40 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Proteasome subunit p40 Rpn8 S12