PRR5 Products

Description

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Bioinformatics

Entrez	55615 Human
Uniprot	NP_056181 Human NP_851850 Human NP_851851 Human P85299 Human
Product By Gene ID	55615
Alternate Names	FLJ20185 FLJ20185k proline rich 5 (renal) protein observed with Rictor-1