Species: Hu, Mu, Rt, Ca, Pm, Pm
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Po, Bv, Ch, Pm, RM, Sh
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: PAGE
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
Bioinformatics
| Product By Gene ID |
5687 |
| Alternate Names |
- EC 3.4.25.1
- IOTA
- Macropain iota chain
- macropain subunit iota
- MGC22756
- MGC2333
- MGC23846
- Multicatalytic endopeptidase complex iota chain
- p27K
- p27KPROS-27
- PROS27
- PROS-27
- PROS2727 kDa prosomal protein
- prosomal P27K protein
- proteasome (prosome, macropain) subunit, alpha type, 6
- Proteasome 20S alpha 6
- Proteasome iota chain
- proteasome subunit alpha type-6
- proteasome subunit iota
- PSMA6
|
