Prominin 2 Products

Antibodies
Prominin 2 Antibody (6B7)
Prominin 2 Antibody (6B7)
Species: Hu
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
Prominin 2 Antibody (244029) ...
Prominin 2 Antibody (244029) [Unco...
MAB2024
Species: Hu
Applications: Flow, ICC
Host: Mouse Monoclonal
Prominin 2 Antibody
Prominin 2 Antibody
NBP2-38032
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Prominin 2 Overexpression Lys ...
Prominin 2 Overexpression Lysate (...
NBP2-11470
Applications: WB
Prominin 2 Overexpression Lys ...
Prominin 2 Overexpression Lysate (...
NBP2-11471
Applications: WB
Prominin 2 Overexpression Lys ...
Prominin 2 Overexpression Lysate (...
NBL1-14811
Applications: WB
Proteins
Prominin 2 Recombinant Protei ...
Prominin 2 Recombinant Protein Ant...
NBP2-38032PEP
Species: Hu
Applications: AC

Description

Prominin 2 is a large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. Several criteria were applied to identify and characterize these new and novel genes. First, a biological signal sequence trap in yeast cells was utilized to identify cDNA clones encoding putative secreted proteins, second strategy utilized various algorithms that recognize features such as the hydrophobic properties of signal sequences to identify putative proteins encoded by expressed sequence tags (ESTs) from human cDNA libraries and finally, ESTs for protein sequence similarity to a set of known receptors and their ligands with the BLAST algorithm. Based on these criteria isolation of full length cDNA clones for each of these genes resulted in identification of more than 1000 novel proteins. One of these new genes is Prominin2. Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30% but their genomic organization is strikingly similar (1). Like Prominin1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues. One striking difference between Prominin1 and Prominin 2 expression lies in its conspicuous absence in eye tissue (2). Prominin 2, along with other genes (AP1M2, MAL2, PRSS8 and FLJ20171) expression is differentially expressed in chromophobe renal cell carcinoma compared to benign oncocytoma consistently and this marker can be used to differentiate RCC form benign oncocytoma (3). Prominin 2 is an androgen-responsive genes proapoptotic membrane protein that is expressed in human prostate and human prostate cancer cell lines with highest levels in less aggressive LNCaP cell and low expression in highly aggressive PC3 and DU145 cells suggesting a role of Prominin 2 in down-regulation of aggressiveness of prostate cancer cells (4).

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 150696
Alternate Names
  • PROM-2
  • hPROML2
  • prominin-related protein
  • PROML2
  • prominin-2
  • Prominin-like protein 2
  • MGC138714
  • prominin 2

Pathways for Prominin 2

View related products by pathway and learn more about each of the pathways below.

Transport
Cell Cycle
Aging
Cell Differentiation
Localization

PTMs for Prominin 2

Learn more about PTMs related to Prominin 2.

Glycosylation
Acetylation

Bioinformatics Tool for Prominin 2

Discover related pathways, diseases and genes to Prominin 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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