PPP2R1B Products

Description

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene. Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID

5519

Alternate Names

MGC26454 PP2A subunit A isoform PR65-beta PP2A subunit A isoform R1-beta PP2A, subunit A, PR65-beta isoform PP2A, subunit A, R1-beta isoform PP2A-Abeta PR65B protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform protein phosphatase 2, regulatory subunit A, beta protein phosphatase 2, structural/regulatory subunit A, beta serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A betaisoform

Research Areas for PPP2R1B

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Protein Phosphatase
Wnt Signaling Pathway