POMC Products

Antibodies
POMC Antibody
POMC Antibody
NB100-1533
Species: Hu, Mu
Applications: WB, IHC, IHC-Fr, IHC-P, PEP-ELISA
Host: Goat Polyclonal
POMC Antibody (2B2)
POMC Antibody (2B2)
NBP2-45369
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
POMC Antibody
POMC Antibody
H00005443-D01P
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Antibody Pairs
POMC Antibody Pair
POMC Antibody Pair
H00005443-PW1
Species: Hu
Applications: WB, IP
Lysates
POMC Overexpression Lysate (D ...
POMC Overexpression Lysate (Denatu...
H00005443-T01
Species: Hu
Applications: WB
POMC Overexpression Lysate (N ...
POMC Overexpression Lysate (Native)
NBL1-14599
Applications: WB
Proteins
Recombinant Human POMC Protei ...
Recombinant Human POMC Protein
H00005443-Q01
Species: Hu
Applications: WB, ELISA, PA
POMC Recombinant Protein Anti ...
POMC Recombinant Protein Antigen
NBP2-57719PEP
Species: Hu
Applications: B/N, Ctrl
POMC Recombinant Protein Anti ...
POMC Recombinant Protein Antigen
NBP2-55008PEP
Species: Hu
Applications: B/N, Ctrl
RNAi
POMC RNAi
POMC RNAi
H00005443-R02
Species: Hu
Applications: RNAi, RNAi SP
POMC RNAi
POMC RNAi
H00005443-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

POMC encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5443
Alternate Names
  • beta-endorphin
  • Corticotropin-lipotropin
  • beta-MSH
  • proopiomelanocortin preproprotein
  • beta-LPH
  • pro-opiomelanocortin
  • alpha-melanocyte-stimulating hormone
  • pro-ACTH-endorphin
  • alpha-MSH
  • met-enkephalin
  • adrenocorticotropin
  • melanotropin gamma
  • adrenocorticotropic hormone
  • melanotropin beta
  • melanotropin alpha
  • lipotropin gamma
  • POC
  • lipotropin beta
  • NPP
  • gamma-MSH
  • MSH
  • gamma-LPH
  • LPH
  • corticotropin-lipotropin
  • CLIP
  • corticotropin-like intermediary peptide
  • ACTH
  • beta-melanocyte-stimulating hormone
  • proopiomelanocortin

Research Areas for POMC

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Nutrient Sensing in the Brain

Bioinformatics Tool for POMC

Discover related pathways, diseases and genes to POMC. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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