POLR1A Products

Antibodies
POLR1A Antibody
POLR1A Antibody
NBP2-32016
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
POLR1A Antibody
POLR1A Antibody
NBP2-56122
Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
Proteins
POLR1A Recombinant Protein An ...
POLR1A Recombinant Protein Antigen
NBP2-56122PEP
Species: Hu
Applications: AC
POLR1A Recombinant Protein An ...
POLR1A Recombinant Protein Antigen
NBP2-32016PEP
Species: Hu
Applications: AC
RNAi
POLR1A RNAi
POLR1A RNAi
H00025885-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition

Bioinformatics

Entrez Human
Product By Gene ID 25885
Alternate Names
  • DNA-directed RNA polymerase I subunit RPA1
  • RPO1-4
  • RPA194
  • RPO14
  • RPA1
  • A190
  • polymerase (RNA) I polypeptide A, 194kDa

Diseases related to POLR1A

Discover more about diseases related to POLR1A.

Malignant Neoplasms
Neoplasms

Pathways for POLR1A

View related products by pathway and learn more about each of the pathways below.

Ribosome Biogenesis
Rrna Transcription
Methylation
Cell Proliferation
Cell Cycle
Dna Methylation
Cell Growth

Bioinformatics Tool for POLR1A

Discover related pathways, diseases and genes to POLR1A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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