PLS1 Products

Description

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. Fimbrin is a 68-kD actin-bundling protein. [provided by RefSeq]

Bioinformatics

Entrez	5357 Human
Uniprot	NP_001138791 Human NP_002661 Human Q14651 Human
Product By Gene ID	5357
Alternate Names	fimbrin I plastin intestine specific plastin Intestine-specific plastin I-plastin plastin 1 (I isoform) plastin 1 plastin-1 Plastin-1