Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLCis subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis ofphosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins andPLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals.Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cellgrowth, signaling and death and maintenance of membrane phospholipids.
|Product By Gene ID
- phosphoinositide phospholipase C-zeta-1
- PI-phospholipase C zeta 1
- testis-development related NYD-SP27
- testis-development protein NYD-SP27
- phospholipase C, zeta 1
Research Areas for PLCZ1
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