PKC zeta Products

Antibodies
PKC zeta Antibody
PKC zeta Antibody
AF6666
Species: Hu
Applications: WB
Host: Sheep Polyclonal
PKC zeta Antibody
PKC zeta Antibody
NB100-82147
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PKC zeta Antibody (453513)
PKC zeta Antibody (453513)
MAB6666
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
PKC zeta Overexpression Lysat ...
PKC zeta Overexpression Lysate (Na...
NBL1-14778
Applications: WB
PKC zeta Overexpression Lysat ...
PKC zeta Overexpression Lysate (Na...
NBP2-11213
Applications: WB
PKC zeta Overexpression Lysat ...
PKC zeta Overexpression Lysate (Na...
NBP2-11050
Applications: WB
Proteins
PKC zeta Partial Recombinant ...
PKC zeta Partial Recombinant Protein
H00005590-Q01
Species: Hu
Applications: WB, ELISA, PA
PKC zeta Recombinant Protein
PKC zeta Recombinant Protein
H00005590-P01
Species: Hu
Applications: WB, ELISA, PA
PKC zeta Recombinant Protein ...
PKC zeta Recombinant Protein Antigen
NBP1-87270PEP
Species: Hu
Applications: AC
RNAi
PKC zeta RNAi
PKC zeta RNAi
H00005590-R01V
Species: Hu
Applications: WB, RNAi, RNAi SP
PKC zeta RNAi
PKC zeta RNAi
H00005590-R06
Species: Hu
Applications: RNAi, RNAi SP
PKC zeta RNAi
PKC zeta RNAi
H00005590-R08
Species: Hu
Applications: RNAi, RNAi SP

Description

Protein kinase C (PKC), a class of serine/threonine kinases activated by Ca2+ and/or phospholipids, is involved in a variety of cellular processes such as proliferation, differentiation and secretion. PKC zeta exhibits a constitutive kinase activity which is independent of Ca2+, phosphatidylserine and diacylglycerol. Arachidonic acid alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhance PKC zeta activity. PKC zeta, in contrast to PKC alpha, is insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain and cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme (1). Results have identified PDK-1 as the kinase that phosphorylates and activates PKC zeta in the PI 3-kinase signaling pathway. This phosphorylation and activation of PKC zeta by PDK-1 is enhanced in the presence of Ptdins-3,4-5-P3. PKCs are enzymes that are regulated at the plasma membrane, and a membrane-targeted PKC zeta is constitutively active in the absence of agonist stimulation. The association between PKC zeta and PDK-1 reveals extensive cross-talk between enzymes in the PI 3-kinase signaling pathway. (2)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 5590
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.13
  • protein kinase C zeta type
  • nPKC-zeta
  • PKC2PKC-ZETA
  • protein kinase C, zeta

Research Areas for PKC zeta

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Diabetes Research
GPCR
Phospho-Specific
Protein Kinase
Signal Transduction
Transcription Factors and Regulators

PTMs for PKC zeta

Learn more about PTMs related to PKC zeta.

Phosphorylation
Cleavage
Myristoylation
Dephosphorylation

Bioinformatics Tool for PKC zeta

Discover related pathways, diseases and genes to PKC zeta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.