PIN/DLC8 Products

Antibodies
PIN/DLC8 Antibody [Unconjugat ...
PIN/DLC8 Antibody [Unconjugated]
AF877
Species: Hu
Applications: WB, IHC, IP
Host: Goat Polyclonal
PIN/DLC8 Antibody (98618)
PIN/DLC8 Antibody (98618)
MAB877
Species: Hu
Applications: WB, IP
Host: Mouse Monoclonal
PIN/DLC8 Antibody (1H7)
PIN/DLC8 Antibody (1H7)
H00008655-M02
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
PIN/DLC8 Overexpression Lysat ...
PIN/DLC8 Overexpression Lysate (Na...
NBP2-10547
Applications: WB
PIN/DLC8 Overexpression Lysat ...
PIN/DLC8 Overexpression Lysate (Na...
NBP2-11201
Applications: WB
PIN/DLC8 Overexpression Lysat ...
PIN/DLC8 Overexpression Lysate (Na...
NBP2-10622
Applications: WB
Proteins
PIN/DLC8 Recombinant Protein
PIN/DLC8 Recombinant Protein
NBP1-49430
Species: Hu
Applications: PAGE

Description

DLC8 protein bound efficiently to gephyrin in in vitro binding assays and colocalized with gephyrin during coexpression in HEK293 cells. The binding site for DLC8 was mapped to a fragment of 63 amino acids within the central linker domain of gephyrin. In hippocampal neurons, endogenous DLC8 protein was enriched at synaptic sites identified by synaptophysin and gephyrin immunostaining. Because DLC8 has been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, results suggest that motor proteins are involved in the subcellular localization of gephyrin. DLC8 was identified as a transport molecule in the cytoplasm. DLC8 co-localizes with TRPS1 in dot-like structures in the cell nucleus. In an electrophoretic mobility shift assay it was shown that the interaction of DLC8 and TRPS1 lowers the binding of TRPS1 to the GATA consensus sequence. In addition DLC8 is able to suppress the transcriptional repression activity of TRPS1.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 8655
Alternate Names
  • Dynein light chain LC8-type 1
  • Protein inhibitor of neuronal nitric oxide synthase
  • HDLC1
  • hdlc1
  • dynein light chain 1, cytoplasmic
  • dynein, cytoplasmic, light polypeptide 1
  • cytoplasmic dynein light polypeptide
  • LC8
  • DNCL1MGC126138
  • DLC8MGC126137
  • PINLC8a
  • DLC1DNCLC1
  • dynein, light chain, LC8-type 1,8 kDa dynein light chain

Research Areas for PIN/DLC8

Find related products by research area and learn more about each of the different research areas below.

p53 Pathway

PTMs for PIN/DLC8

Learn more about PTMs related to PIN/DLC8.

Phosphorylation
Nitration
Reduction
Glycosylation
Dephosphorylation

Bioinformatics Tool for PIN/DLC8

Discover related pathways, diseases and genes to PIN/DLC8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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