PIK3C2A Products

Description

PIK3C2A belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Bioinformatics

Entrez	18704 Mouse 5286 Human
Uniprot	NM_002645 Human NP_002636 Human NP_002636. Human O00443 Human
Product By Gene ID	5286
Alternate Names	C2-containing phosphatidylinositol kinase CPK DKFZp686L193 EC 2.7.1 EC 2.7.1.154 MGC142218 phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphoinositide 3-kinase-C2-alpha phosphoinositide-3-kinase, class 2, alpha polypeptide PI3-K-C2(ALPHA) PI3-K-C2A PI3K-C2alpha PI3K-C2-alpha PtdIns-3-kinase C2 subunit alpha

Research Areas for PIK3C2A

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction