Phosphodiesterase 4A/PDE4A Products

Antibodies
Phosphodiesterase 4A/PDE4A An ...
Phosphodiesterase 4A/PDE4A Antibod...
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Phosphodiesterase 4A/PDE4A An ...
Phosphodiesterase 4A/PDE4A Antibody
NBP2-33388
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Phosphodiesterase 4A/PDE4A [p ...
Phosphodiesterase 4A/PDE4A [p Ser6...
NB300-635
Species: Hu, Mu, Rt, Ch, Pm
Applications: WB
Host: Rabbit Polyclonal
Lysates
Phosphodiesterase 4A/PDE4A Ov ...
Phosphodiesterase 4A/PDE4A Overexp...
H00005141-T01
Species: Hu
Applications: WB
Phosphodiesterase 4A/PDE4A Ov ...
Phosphodiesterase 4A/PDE4A Overexp...
NBP2-09382
Applications: WB
Proteins
Phosphodiesterase 4A/PDE4A Re ...
Phosphodiesterase 4A/PDE4A Recombi...
H00005141-P01
Species: Hu
Applications: WB, ELISA, PA
Phosphodiesterase 4A/PDE4A Re ...
Phosphodiesterase 4A/PDE4A Recombi...
NBP2-33388PEP
Species: Hu
Applications: AC

Description

Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are also important molecular targets for a variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprises 4 genes (PDE4A, B, C and D); each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants. Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases. Protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling. In brain members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 5141
Alternate Names
  • EC 3.1.4
  • PDE4
  • phosphodiesterase isozyme 4
  • phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E2)
  • phosphodiesterase E2 dunce homolog, Drosophila
  • EC 3.1.4.17
  • phosphodiesterase 4A, cAMP-specific (dunce
  • PDE46
  • DPDE2cAMP-specific phosphodiesterase
  • cAMP-specific 3'-5'-cyclic phosphodiesterase 4A
  • phosphodiesterase 4A, cAMP-specific

Research Areas for Phosphodiesterase 4A/PDE4A

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Signal Transduction
Stem Cell Markers

PTMs for Phosphodiesterase 4A/PDE4A

Learn more about PTMs related to Phosphodiesterase 4A/PDE4A.

Phosphorylation
Cleavage
Sumoylation
Methylation

Bioinformatics Tool for Phosphodiesterase 4A/PDE4A

Discover related pathways, diseases and genes to Phosphodiesterase 4A/PDE4A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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