PHAX Products

Antibodies
PHAX Antibody
PHAX Antibody
NBP2-22268
Species: Hu, Mu, Equine, Ferret, Guinea Pig, Primate, Porcine, Rabbit, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
PHAX Antibody
PHAX Antibody
NBP2-48821
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
PHAX Antibody
PHAX Antibody
NBP2-19792
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
PHAX Overexpression Lysate (N ...
PHAX Overexpression Lysate (Native)
NBL1-15472
Applications: WB
Proteins
PHAX Recombinant Protein
PHAX Recombinant Protein
H00051808-P01
Species: Hu
Applications: WB, ELISA, PA
PHAX Recombinant Protein Anti ...
PHAX Recombinant Protein Antigen
NBP2-48821PEP
Species: Hu
Applications: AC

Description

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 51808
Alternate Names
  • RNUXA
  • RNA U, small nuclear RNA export adapter (phosphorylation regulated)
  • RNA U, small nuclear RNA export adaptor (phosphorylation regulated)
  • phosphorylated adapter RNA export protein
  • FLJ13193
  • RNA U small nuclear RNA export adapter protein
  • phosphorylated adaptor for RNA export

Diseases related to PHAX

Discover more about diseases related to PHAX.

Neurodegenerative Disorders
Muscular Atrophy
Atrophy
Spinal Muscular Atrophy

Pathways for PHAX

View related products by pathway and learn more about each of the pathways below.

Nuclear Export
Transport
Localization
Rna Interference
Ribosome Biogenesis
Nucleocytoplasmic Transport
Nuclear Import
Rna Processing
Snorna Processing

PTMs for PHAX

Learn more about PTMs related to PHAX.

Phosphorylation
Dephosphorylation
Methylation

Bioinformatics Tool for PHAX

Discover related pathways, diseases and genes to PHAX. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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