PFKFB1 Products

Antibodies
PFKFB1 Antibody
PFKFB1 Antibody
H00005207-D01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Lysates
PFKFB1 Overexpression Lysate ...
PFKFB1 Overexpression Lysate (Dena...
H00005207-T01
Species: Hu
Applications: WB
PFKFB1 Overexpression Lysate ...
PFKFB1 Overexpression Lysate (Native)
NBP2-08088
Applications: WB
Proteins
PFKFB1 Recombinant Protein
PFKFB1 Recombinant Protein
H00005207-P01
Species: Hu
Applications: WB, ELISA, PA
PFKFB1 Partial Recombinant Pr ...
PFKFB1 Partial Recombinant Protein
H00005207-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PFKFB1 RNAi
PFKFB1 RNAi
H00005207-R03
Species: Hu

Description

Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2), and ADP. Human PFK-1 is tetrameric and isoenzymes include, PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B), and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2,6-bisphosphate, and contains fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).

Bioinformatics

Uniprot Human
Human
Product By Gene ID 5207
Alternate Names
  • 2-kinase:fructose-2,6-bisphosphatase
  • fructose-6-phosphate
  • F6PK
  • MGC116717
  • MGC116715,6PF-2-K/Fru-2,6-P2ase 1
  • 6PF-2-K/Fru-2,6-P2ase liver isozyme
  • PFRXHL2K
  • PFK/FBPase 1
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Pathways for PFKFB1

View related products by pathway and learn more about each of the pathways below.

Glycolysis
Localization
Cell Proliferation
Cell Cycle
Insulin Secretion
Complement Activation
Angiogenesis
Cell Cycle Arrest
Secretion

PTMs for PFKFB1

Learn more about PTMs related to PFKFB1.

Phosphorylation
Cleavage

Bioinformatics Tool for PFKFB1

Discover related pathways, diseases and genes to PFKFB1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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