PDE7A Products

Antibodies
PDE7A Antibody
PDE7A Antibody
NBP1-83275
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
PDE7A Antibody
PDE7A Antibody
NB110-40453
Species: Hu, Bt, Bv, Ca, Mk, Pm, Rb, Xp, Hamster, Mouse, Opossum, Rat, Turkey
Applications: IHC-P
Host: Rabbit Polyclonal
PDE7A Antibody
PDE7A Antibody
NB300-639
Species: Hu, Mu, Rt
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
PDE7A Overexpression Lysate ( ...
PDE7A Overexpression Lysate (Native)
NBP2-08091
Applications: WB
PDE7A Overexpression Lysate ( ...
PDE7A Overexpression Lysate (Native)
NBL1-14230
Applications: WB
Proteins
PDE7A Partial Recombinant Pro ...
PDE7A Partial Recombinant Protein
H00005150-Q01
Species: Hu
Applications: WB, ELISA, PA
PDE7A Recombinant Protein
PDE7A Recombinant Protein
H00005150-P01
Species: Hu
Applications: WB, ELISA, PA
PDE7A Recombinant Protein Ant ...
PDE7A Recombinant Protein Antigen
NBP1-83275PEP
Species: Hu
Applications: AC
RNAi
PDE7A RNAi
PDE7A RNAi
H00005150-R02
Species: Hu
PDE7A RNAi
PDE7A RNAi
H00005150-R01
Species: Hu

Description

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in T Lymphocytes are phosphodiesterase type 7. The cAMP specific phosphodiesterase type 7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE7A has two splice variants (PDE7A1 and PDE7A2). The two are divergent at the 5 prime end in human, and PDE7A1 is more hydrophobic. Like other PDEs, human PDE7A gene has 456 amino acids and migrates at an apparent molecular weight of 53 to 55 kDa on reduced SDS PAGE. The PDE7A has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE7A protein showed significant homology to other cAMP dependent PDEs (23%) with in the catalytic domain. PDE7A is widely expressed in various tissues including skeletal muscle, T lymphocytes, brain and pancreas.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 5150
Alternate Names
  • EC 3.1.4
  • EC 3.1.4.17
  • phosphodiesterase isozyme 7
  • TM22
  • HCP1high affinity cAMP-specific 3'-5'-cyclic phosphodiesterase 7A
  • PDE7
  • phosphodiesterase 7A

Research Areas for PDE7A

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for PDE7A

Learn more about PTMs related to PDE7A.

Phosphorylation
Cleavage

Bioinformatics Tool for PDE7A

Discover related pathways, diseases and genes to PDE7A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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