PDE6H Products

PDE6H Overexpression Lysate ( ...
PDE6H Overexpression Lysate (Native)
Applications: WB
PDE6H Recombinant Protein
PDE6H Recombinant Protein
Species: Hu
Applications: PAGE


Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.


Uniprot Human
Product By Gene ID 5149
Alternate Names
  • EC
  • EC
  • retinal cone rhodopsin-sensitive cGMP 3'-5'-cyclic phosphodiesterase subunitgamma
  • RCD3
  • GMP-PDE gamma
  • phosphodiesterase 6H, cGMP-specific, cone, gamma

Pathways for PDE6H

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Mrna Processing

Research Areas for PDE6H

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Signal Transduction

PTMs for PDE6H

Learn more about PTMs related to PDE6H.


Bioinformatics Tool for PDE6H

Discover related pathways, diseases and genes to PDE6H. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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