PDE4B Products

Antibodies
PDE4B Antibody (1D12)
PDE4B Antibody (1D12)
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
PDE4B Antibody
PDE4B Antibody
NBP1-84057
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PDE4B Antibody
PDE4B Antibody
NB100-2562
Species: Mu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
PDE4B Overexpression Lysate ( ...
PDE4B Overexpression Lysate (Native)
NBP2-08546
Applications: WB
PDE4B Overexpression Lysate ( ...
PDE4B Overexpression Lysate (Native)
NBL1-14219
Applications: WB
PDE4B Overexpression Lysate ( ...
PDE4B Overexpression Lysate (Native)
NBL1-14220
Applications: WB
Proteins
PDE4B Partial Recombinant Pro ...
PDE4B Partial Recombinant Protein
H00005142-Q01
Species: Hu
Applications: WB, ELISA, PA
PDE4B Recombinant Protein Ant ...
PDE4B Recombinant Protein Antigen
NBP1-84057PEP
Species: Hu
Applications: AC

Description

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. Four genes (PDE4A, B, C and D) make up the PDE4 family. cAMP-dependent phosphodiesterase type B (PDE4B) family consists of four known splice variants, PDE4B1, B2, B3 and a novel 66 kDa PDE4B4 protein. One or more subtype variants of PDE4B are ubiquitously present in all mammalian cells. In CNS, all four PDE4B subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Some PDE4B variants are also substrate for PKA-dependent phosphorylation. Peripheral tissues exhibit differential expression of PDE4B1, B2 and B4 variants; the PDE4B4 (66kDa protein) is the major PDE4B variant expressed in lungs, testis and heart. In testis PDE4B enzymes are expressed in somatic cells (Sertoli and Leydig cells) while PDE4A is localized in germ cells.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5142
Alternate Names
  • EC 3.1.4
  • phosphodiesterase E4 dunce homolog
  • MGC126529
  • phosphodiesterase 4B, cAMP-specific (dunce
  • DKFZp686F2182
  • dunce-like phosphodiesterase E4
  • phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E4)
  • cAMP-specific phosphodiesterase-4 B isoform
  • EC 3.1.4.17
  • cAMP-specific 3'-5'-cyclic phosphodiesterase 4B
  • PDE32
  • PDEIVB
  • Drosophila)
  • cAMP-specific (phosphodiesterase E4 dunce homolog
  • phosphodiesterase 4B, cAMP-specific

Research Areas for PDE4B

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction

PTMs for PDE4B

Learn more about PTMs related to PDE4B.

Phosphorylation
Cleavage
Methylation
Acetylation
Dephosphorylation

Bioinformatics Tool for PDE4B

Discover related pathways, diseases and genes to PDE4B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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