Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.
|Product By Gene ID
- EC 188.8.131.52
- EC 2.7.11
- p21-activated kinase 4
- serine/threonine-protein kinase PAK 4
- p21(CDKN1A)-activated kinase 4
- protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
- p21 protein (Cdc42/Rac)-activated kinase 4
Research Areas for PAK4+5+6
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