Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
55824 |
| Alternate Names |
- CBPMGC138364
- Csk-binding protein
- PAGFLJ37858
- phosphoprotein associated with glycosphingolipid microdomains 1
- phosphoprotein associated with glycosphingolipid-enriched microdomains 1
- Transmembrane adapter protein PAG
- Transmembrane phosphoprotein Cbp
|
