PAG1 Products

Antibodies
PAG1 Antibody (504004) [Uncon ...
PAG1 Antibody (504004) [Unconjugated]
MAB5285
Species: Hu
Applications: WB, Simple Western
Host: Mouse Monoclonal
PAG1 Antibody
PAG1 Antibody
AF5285
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Lysates
PAG1 Overexpression Lysate (N ...
PAG1 Overexpression Lysate (Native)
NBL1-14068
Applications: WB
Proteins
PAG1 Recombinant Protein Anti ...
PAG1 Recombinant Protein Antigen
NBP1-88173PEP
Species: Hu
Applications: AC
PAG1 Recombinant Protein
PAG1 Recombinant Protein
P5034
Species: Hu
Applications: PAGE

Description

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 55824
Alternate Names
  • Transmembrane phosphoprotein Cbp
  • phosphoprotein associated with glycosphingolipid-enriched microdomains 1
  • Transmembrane adapter protein PAG
  • CBPMGC138364
  • PAGFLJ37858
  • Csk-binding protein
  • phosphoprotein associated with glycosphingolipid microdomains 1

Research Areas for PAG1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cellular Markers
Chromatin Research
HIF Target Genes
Hypoxia
Membrane Trafficking and Chaperones
Signal Transduction
Transcription Factors and Regulators

Bioinformatics Tool for PAG1

Discover related pathways, diseases and genes to PAG1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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