PABP Products

Antibodies
PABP Antibody
PABP Antibody
NBP2-19670
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PABP Antibody
PABP Antibody
H00026986-D01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Lysates
PABP Overexpression Lysate (N ...
PABP Overexpression Lysate (Native)
NBP2-10839
Applications: WB
PABP Overexpression Lysate (D ...
PABP Overexpression Lysate (Denatu...
H00026986-T02
Applications: WB
Proteins
PABP Recombinant Protein
PABP Recombinant Protein
H00026986-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PABP RNAi
PABP RNAi
H00026986-R01
Species: Hu

Description

The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. Grange et al. (1987) isolated a melanoma cell cDNA encoding human PABP. The predicted 633-amino acid protein contains 4 repeats of an approximately 80-amino acid unit in its N-terminal half. The authors found that this repeat region is highly conserved between human and yeast PABP and is sufficient for poly(A) binding. In vitro translation of the human PABP cDNA yielded a protein with an apparent molecular mass of 73 kD by SDS-PAGE. Northern blot analysis indicated that PABP is expressed as a 2.9-kb mRNA in human melanoma cells. Gorlach et al. (1994) noted that each of the 4 repeats of PABP is a ribonucleoprotein (RNP) consensus sequence RNA-binding domain. They determined that PABP has a pI of approximately 10.3 and is a very abundant, stable protein. Immunofluorescence studies of mammalian cells indicated that PABP is located exclusively in the cytoplasm. However, using both indirect immunofluorescence and tagging of PABP1 by fusion to the green fluorescent protein (GFP), Afonina et al. (1998) demonstrated that PABP1 shuttles between the nucleus and cytoplasm. PABP1 accumulated in the nucleus when transcription was inhibited, suggesting that active transcription is required for nuclear export of PABP1.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 26986
Alternate Names
  • PABP
  • Poly(A)-binding protein 1
  • PABPC2
  • PABP-1
  • PABPL1
  • PAB1polyadenylate-binding protein 1
  • PABP1poly(A) binding protein, cytoplasmic 2
  • poly(A)-binding protein, cytoplasmic 2
  • poly(A) binding protein, cytoplasmic 1

Research Areas for PABP

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
DNA Repair
DNA replication, Transcription, Translation and Splicing
Stem Cell Markers

PTMs for PABP

Learn more about PTMs related to PABP.

Phosphorylation
Cleavage
Methylation
Acetylation
Ubiquitination

Bioinformatics Tool for PABP

Discover related pathways, diseases and genes to PABP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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