Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein and SIP (for stress induced protein) in human and mouse. A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks. p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-a and p53DINP1-b or SIP27 and SIP18. p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress.
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
94241 |
| Alternate Names |
- DKFZp434M1317
- FLJ22139
- p53DINP1
- P53DINP1p53-dependent damage-inducible nuclear protein 1
- p53-inducible p53DINP1
- SIPStress-induced protein
- Teap
- TP53DINP1
- TP53INP1A
- TP53INP1B
- tumor protein p53 inducible nuclear protein 1
- tumor protein p53-inducible nuclear protein 1
|
