p53 AIP1 Products

Antibodies
p53 AIP1 Antibody
p53 AIP1 Antibody
NBP1-76742
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
p53 AIP1 Antibody
p53 AIP1 Antibody
NBP1-47159
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
p53 AIP1 Antibody
p53 AIP1 Antibody
NBP2-48917
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Proteins
p53 AIP1 Recombinant Protein ...
p53 AIP1 Recombinant Protein Antigen
NBP2-13465PEP
Species: Hu
Applications: AC
p53 AIP1 Recombinant Protein ...
p53 AIP1 Recombinant Protein Antigen
NBP2-48917PEP
Species: Hu
Applications: AC
p53 AIP1 Recombinant Protein
p53 AIP1 Recombinant Protein
NBP2-22909
Species: Hu
Applications: PAGE
RNAi
p53 AIP1 RNAi
p53 AIP1 RNAi
H00063970-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The novel protein p53 AIP1, p53-regulated apoptosis inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53 AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46,p53 AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53 AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53 AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser 46 regulates the transcriptional activation of this apoptosis inducing gene.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 63970
Alternate Names
  • p53-regulated apoptosis-inducing protein 1
  • P53AIP1
  • p53AIP1
  • tumor protein p53 regulated apoptosis inducing protein 1

Diseases related to p53 AIP1

Discover more about diseases related to p53 AIP1.

Malignant Neoplasm Of Prostate
Malignant Neoplasms
Prostatic Neoplasms
Neoplasms

Research Areas for p53 AIP1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
DNA Repair

Bioinformatics Tool for p53 AIP1

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