OVCA1 Products

Description

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM]

Bioinformatics

Uniprot	NP_001374 Human Q9BZG8 Human
Product By Gene ID	1801
Alternate Names	Diphthamide biosynthesis protein 2 homolog-like 1 Diphthamide biosynthesis protein 2-like diptheria toxin resistance protein required for diphthamide biosynthesis(Saccharomyces)-like 1 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1(S. cerevisiae) DPH1 homolog (S. cerevisiae) DPH1 homolog DPH2L DPH2L1diphthamide biosynthesis protein 1 DPH2-like 1 DPH-like 1 (S. cerevisiae) DPH-like 1 FLJ33211 hsDph1 HsDph1 Ovarian cancer-associated gene 1 protein ovarian tumor suppressor candidate 1 OVCA1candidate tumor suppressor in ovarian cancer 1