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Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein responsetarget genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (Bysimilartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-likesequences, and activates transcription through box-B element but not through CRE
