NUP98 Products

Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]

Bioinformatics

Uniprot	A8KA17 Human AAH12906 Human NP_057404.2 Human P52948 Human
Product By Gene ID	4928
Alternate Names	ADAR2 ADIR2 GLFG-repeat containing nucleoporin nuclear pore complex protein Nup98-Nup96 nucleoporin 98kD nucleoporin 98kDa NUP196 NUP96 Nup98-Nup96

Research Areas for NUP98

Find related products by research area and learn more about each of the different research areas below.

Cancer
Mitotic Regulators