NUP98 Products

Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]

Bioinformatics

Uniprot	P52948 Human NP_057404.2 Human A8KA17 Human AAH12906 Human
Product By Gene ID	4928
Alternate Names	ADAR2 NUP196 nuclear pore complex protein Nup98-Nup96 ADIR2 GLFG-repeat containing nucleoporin nucleoporin 98kD NUP96 Nup98-Nup96 nucleoporin 98kDa

Diseases related to NUP98

Discover more about diseases related to NUP98.

Leukemia
Myeloid Leukemia
Leukemia, Myelocytic, Acute
Chromosomal Translocation
Malignant Neoplasms
Leukemogenesis
Cell Transformation, Neoplastic
Dysmyelopoietic Syndromes
Myeloid Leukemia, Chronic
Cytogenetic Abnormality
Hematologic Neoplasms
Neoplasms
Acute Lymphocytic Leukemia
Acute Leukemia
Blast Phase
Malignant Paraganglionic Neoplasm
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Therapy-related Myelodysplastic Syndrome

Pathways for NUP98

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Transport
Localization
Nuclear Export
Nuclear Transport
Mitosis
Nuclear Import
Pathogenesis
Nucleocytoplasmic Transport
Cell Cycle
Translation
Metaphase
Methylation
Protein Import
Cell Proliferation
Proteolysis
Chromosome Segregation
Anaphase
Reverse Transcription
Rna Interference
Interphase

Research Areas for NUP98

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Cancer
Mitotic Regulators

PTMs for NUP98

Learn more about PTMs related to NUP98.

Cleavage
Phosphorylation
Methylation
Ubiquitination
Acetylation
Glycosylation
Prenylation

Bioinformatics Tool for NUP98

Discover related pathways, diseases and genes to NUP98. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.