NPIP Products

Description

The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).

Bioinformatics

Uniprot	NP_008916 Human Q86VD5 Human
Product By Gene ID	9284
Alternate Names	FLJ42525 FLJ44848 nuclear pore complex interacting protein nuclear pore complex-interacting protein

Research Areas for NPIP

Find related products by research area and learn more about each of the different research areas below.

Neuroscience