Noxa Products

Antibodies
Noxa Antibody
Noxa Antibody
NB100-56368
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Noxa Overexpression Lysate
Noxa Overexpression Lysate
NBL1-14534
Species: Hu
Applications: WB
Proteins
Recombinant Human Noxa GST (N ...
Recombinant Human Noxa GST (N-Term...
H00005366-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Noxa Recombinant Protein Anti ...
Noxa Recombinant Protein Antigen
NBP2-48996PEP
Species: Hu
Applications: AC

Description

Noxa, phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, PMAIP1 (Human 6 kDa and Mouse 11.6 kDa) is a Bcl2 homology 3 (BH3) domain containing protein which plays a role in the regulation of apoptosis, specifically a pro-apoptotic role. Human Noxa contains only one BH3 domain, while the mouse and rat proteins contain two BH3 domains. The human protein is encoded by Exon 1 and 3, with Exon 2 present only in two splice variants. Human Noxa splice variants lack a BH3 domain, have no known function, and are rapidly targeted for degradation (1).

Noxa mediated apoptosis may follow its transcriptional activation by p53 as part of the DNA damage response. However, Noxa expression may be induced by HIF-1 alpha under hypoxia, promoting apoptosis independently of p53 (1). Inhibition of the anti-apoptotic Bcl2 family member Myeloid cell leukemia-1 (Mcl-1) by Noxa, leads to the activation of pro-apoptotic Bcl2 homologous antagonist killer (Bak) and Bcl2 associated X (Bax) proteins, and apoptosis through the intrinsic mitochondrial pathway (2). Other BH3 only proteins such as Bim, Puma, Bad and Bid act via the same mechanism, targeting Mcl-1 and inducing Bak/Bax mediated mitochondrial outer membrane permeabilization (MOMP), cytochrome c release and caspase 9 activation (3). Overexpression of antiapoptotic Bcl2 family members is common in various types of cancer including prostate cancer. A recent study identified antiapoptotic Bcl2 proteins involved in the development of resistance towards the androgen receptor antagonist enzalutamide, which is used for the treatment of metastatic castration-resistant prostate cancer (mCRPC) (3).

References

1.Ploner, C., Kofler, R., & Villunger, A. (2008). Noxa: At the tip of the balance between life and death. Oncogene. https://doi.org/10.1038/onc.2009.46

2.Xiang, W., Yang, C. Y., & Bai, L. (2018). MCL-1 inhibition in cancer treatment. OncoTargets and Therapy. https://doi.org/10.2147/OTT.S146228

3.Pilling, A. B., & Hwang, C. (2019). Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide. Prostate. https://doi.org/10.1002/pros.23843

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 5366
Alternate Names
  • PMA-Induced Protein 1
  • Immediate-early-response protein APR
  • adult T cell leukemia-derived PMA-responsive
  • APR
  • NOXAPMA-induced protein 1
  • Protein Noxa
  • phorbol-12-myristate-13-acetate-induced protein 1

Research Areas for Noxa

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cellular Markers
Membrane Trafficking and Chaperones
Plasma Membrane Markers
Stem Cell Markers
Tumor Suppressors

Bioinformatics Tool for Noxa

Discover related pathways, diseases and genes to Noxa. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Noxa Blog Posts

Check out the latest blog posts on Noxa.
NOXA - a BH3-only protein balancing cell death decisions
Noxa is a BH3-only protein involved in regulating cell death decisions. Noxa is a primary p53-response gene and is upregulated in response to p53 overexpression or DNA damage. Noxa can also be induced by alternative mechanisms including through a ...    Read more.
Understanding Noxa Regulation of Apoptosis
Noxa is a pro-apoptotic gene belonging to the Bcl2 protein family that is unique in that it contains only BH3 domain. The BH3-only subclass of proteins, including proteins like PUMA and Bim in addition to Noxa, regulate the remaining Bcl-2 family memb...    Read more.
Read more Noxa related blogs.