Hu, Mu, RtApplications:
WB, Flow, ICC/IF, IHC, IHC-PHost:
WB, ICC/IF, IHC, IHC-PHost:
Applications: WB, Flow, IHC, IHC-P
Host: Rabbit Monoclonal
Applications: WB, ELISA, PA, PAGE, AP
Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage) (1). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al (1) have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis.
|Product By Gene ID
- Immediate-early-response protein APR
- adult T cell leukemia-derived PMA-responsive
- NOXAPMA-induced protein 1
- Protein Noxa
- phorbol-12-myristate-13-acetate-induced protein 1
Bioinformatics Tool for Noxa
Discover related pathways, diseases and genes to Noxa. Need help? Read the Bioinformatics Tool Guide
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Related Noxa Blog Posts
Check out the latest blog posts on Noxa.
Read more Noxa related blogs.
|NOXA - a BH3-only protein balancing cell death decisions
Noxa is a BH3-only protein involved in regulating cell death decisions. Noxa is a primary p53-response gene and is upregulated in response to p53 overexpression or DNA damage. Noxa can also be induced by alternative mechanisms including through a ... Read more.
|Understanding Noxa Regulation of Apoptosis
Noxa is a pro-apoptotic gene belonging to the Bcl2 protein family that is unique in that it contains only BH3 domain. The BH3-only subclass of proteins, including proteins like PUMA and Bim in addition to Noxa, regulate the remaining Bcl-2 family memb... Read more.