Notch-2 Products

Antibodies
Notch-2 Antibody
Notch-2 Antibody
AF1190
Species: Rt
Applications: WB, Flow, IHC, Block
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Notch-2 Antibody [Unconjugate ...
Notch-2 Antibody [Unconjugated]
AF3735
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Notch-2 Antibody
Notch-2 Antibody
NBP2-47351
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Notch-2 Partial Recombinant P ...
Notch-2 Partial Recombinant Protein
H00004853-Q01
Species: Hu
Applications: WB, ELISA, PA
Notch-2 Recombinant Protein A ...
Notch-2 Recombinant Protein Antigen
NBP2-47351PEP
Species: Hu
Applications: AC
Notch-2 Recombinant Protein A ...
Notch-2 Recombinant Protein Antigen
NBP2-48913PEP
Species: Hu
Applications: AC
RNAi
Notch-2 RNAi
Notch-2 RNAi
H00004853-R01
Species: Hu

Description

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membraneFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 4853
Alternate Names
  • Notch (Drosophila) homolog 2
  • Notch homolog 2
  • AGS2
  • neurogenic locus notch homolog protein 2
  • hN2
  • notch 2Notch homolog 2 (Drosophila)

Research Areas for Notch-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Signal Transduction
Stem Cell Signaling Pathway

Bioinformatics Tool for Notch-2

Discover related pathways, diseases and genes to Notch-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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