Applications: WB, Flow, IHC, Block, CyTOF-ready
Host: Goat Polyclonal
Species: Mu, Rt
Host: Sheep Polyclonal
Applications: WB, ELISA, PA
Applications: WB, ELISA, IP
Applications: RNAi, RNAi SP
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membraneFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
|Product By Gene ID
- Notch (Drosophila) homolog 2
- Notch homolog 2
- neurogenic locus notch homolog protein 2
- notch 2Notch homolog 2 (Drosophila)
Bioinformatics Tool for Notch-2
Discover related pathways, diseases and genes to Notch-2. Need help? Read the Bioinformatics Tool Guide
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