NMDAR1 Products

Antibodies
NMDAR1 Antibody (R1JHL)
NMDAR1 Antibody (R1JHL)
NB300-118
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
NMDAR1 Antibody (JM11-26)
NMDAR1 Antibody (JM11-26)
NBP2-66982
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
ELISA Kits
Human NMDAR1 ELISA Kit (Color ...
Human NMDAR1 ELISA Kit (Colorimetric)
NBP2-68021
Species: Hu
Applications: ELISA
Lysates
NMDAR1 Overexpression Lysate
NMDAR1 Overexpression Lysate
NBP2-11163
Species: Hu
Applications: WB
NMDAR1 Overexpression Lysate
NMDAR1 Overexpression Lysate
NBP2-10710
Species: Hu
Applications: WB
NMDAR1 Overexpression Lysate
NMDAR1 Overexpression Lysate
NBL1-11338
Species: Hu
Applications: WB
Proteins
Recombinant Human NMDAR1 GST ...
Recombinant Human NMDAR1 GST (N-Te...
H00002902-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human NMDAR1 Prot ...
Recombinant Human NMDAR1 Protein
H00002902-G01-10ug
Species: Hu
Applications: AP

Description

N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that have a high permeability to calcium found in the central nervous system. The receptor consists of a number of distinct ligand binding domains, and the presence of both glutamate and glycine are required for full activation of the channel. Within the channel there is also a binding site for magnesium, which, when occupied, propagates a voltage-dependent channel block. Other binding sites are also found in the receptor, including a zinc-binding site and an inter-channel site that binds specific channel blockers such as phencyclidine (PCP) and related compounds. The NMDA receptor has been demonstrated to play an essential role in long-term potentiation (LTP), a phenomenon that has been implicated to be the basis for learning and memory. The influx of calcium as a result of channel activation is thought to be responsible for neuronal plasticity and glutamate neurotoxicity. A number of different NMDA receptor subunits have been cloned that may possess different functional and localization properties. The NMDA-R1 subunit (NR1) is expressed throughout the brain, while the NMDA-R2 subunits (NR2A, NR2B, NR2C, and NR2D) have a more specific localization pattern. The NMDA receptor subunits differ also in glycine sensitivity, the relative strength of the magnesium channel block, and their respective agonist-dependent deactivation time.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 2902
Alternate Names
  • NMDA1
  • N-methyl-D-aspartate receptor channel, subunit zeta-1
  • N-methyl-D-aspartate receptor subunit NR1
  • glutamate [NMDA] receptor subunit zeta-1
  • NMD-R1
  • NMDAR1glutamate [NMDA] receptor subunit zeta 1
  • NR1
  • glutamate receptor, ionotropic, N-methyl D-aspartate 1

Research Areas for NMDAR1

Find related products by research area and learn more about each of the different research areas below.

Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific

PTMs for NMDAR1

Learn more about PTMs related to NMDAR1.

Phosphorylation
Reduction
Glycosylation
Methylation

Bioinformatics Tool for NMDAR1

Discover related pathways, diseases and genes to NMDAR1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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