NKX2.6 Products

NKX2.6 Antibody
NKX2.6 Antibody
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal


Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas.Nkx-2.5, also designated cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. Nkx-2.5 binds to DNA as a monomer, a homodimer or as a heterodimer with Nkx-2.3 or Nkx-2.6, which suggests that the specific protein-protein interactions of Nkx-2.5 are involved in its transcriptional regulatory function. Nkx-2.6, also a homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches,the caudal heart progenitors, the sinus venosus, the outflow tract of the heart and in a short segment of the gut between stages E8.5 and E10.5 of embryogenesis. Expression of Nkx-2.6 overlaps with that of Nkx-2.5 in the pharynx and heart. However, Nkx-2.6 mutant mice are viable and fertile, which suggests that Nkx-2.6 plays a compensatory function to Nkx-2.5.


Uniprot Human
Product By Gene ID 137814
Alternate Names
  • NKX4-2
  • NKX2F
  • CSX2
  • NK2 homeobox 6

Pathways for NKX2.6

View related products by pathway and learn more about each of the pathways below.

Heart Development
Cell Proliferation
Epithelial Cell Development
Cell Development
Head Development
Thymus Development

Bioinformatics Tool for NKX2.6

Discover related pathways, diseases and genes to NKX2.6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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