NKX2.5 Products

Description

Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM]

Bioinformatics

Uniprot	AAH25711 Human NM_004387 Human NP_004378 Human NP_004378.1 Human
Product By Gene ID	1482
Alternate Names	cardiac-specific homeo box cardiac-specific homeobox 1 Cardiac-specific homeobox CHNG5 CSX1 CSXFLJ97195 FLJ52202 FLJ99536 Homeobox protein CSX Homeobox protein NK-2 homolog E homeobox protein Nkx-2.5 NK2 transcription factor related, locus 5 (Drosophila) NKX2.5FLJ97166 NKX2EFLJ97197 NKX4-1 tinman paralog