NFX1 Products

Description

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Bioinformatics

Uniprot	NM_002504 Human NP_002495 Human
Product By Gene ID	4799
Alternate Names	DKFZp779G2416 EC 6.3.2.- MGC20369 NFX2transcriptional repressor NF-X1 Nuclear transcription factor, X box-binding protein 1 nuclear transcription factor, X-box binding 1

Research Areas for NFX1

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