WB, Simple Western, ICC/IF, IHC, IHC-PHost:
Species: Hu, Mu
Applications: WB, ChIP
Host: Goat Polyclonal
Nuclear factor kappa beta (NFKB) is a transcription factor that is highly influenced by stress, free-radicals, UV light and hypoxia. Unsurprisingly, NFKB is essential for many human cancers, as it regulates the expression of many downstream proteins that regulate or modify cellular growth and development. NFKB effects on angiogenic pathways and reactive mechanisms to stress and damage are well established throughout literature. Atherosclerosis is partly attributed to the mis-regulation of NFKB in hypoxia. Arthritis is related to inflammation proteins regulated through NFKB. It also has been shown to be important in synapses in brain, leading to memory and cognitive ability or impairment. In all, NFKB is one of the fastest responding transcription factors in humans, and is likely to mediate many responsive events in diseases and injury recovery.
|Product By Gene ID
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- DNA-binding factor KBF1
- Nuclear factor NF-kappa-B p105 subunit
Bioinformatics Tool for NFkB1/NFkB p105
Discover related pathways, diseases and genes to NFkB1/NFkB p105. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.