NDUFS2 Products

Description

Mitochondrial complex I (NADH-ubiquinone reductase; EC 1.6.5.3) is the first multimeric complex of the respiratory chain that catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mammalian mitochondrial complex I is an assembly of at least 43 different subunits. Seven of the subunits are encoded by the mitochondrial genome; the remainder are the products of nuclear genes. The iron-sulfur protein (IP) fraction of complex I is made up of 7 subunits, including NDUFS2. See NDUFS1 (MIM 157655).[supplied by OMIM]

Bioinformatics

Uniprot	NP_004541 Human NP_004541.1 Human NM_004550 Human
Product By Gene ID	4720
Alternate Names	complex 1, mitochondrial respiratory chain, 49-KD subunit EC 1.6.99.5 NADH dehydrogenase (ubiquinone) Fe-S protein 2 (49kD) (NADH-coenzyme Qreductase) EC 1.6.99.3 NADH-ubiquinone oxidoreductase 49 kDa subunit EC 1.6.5.3 CI-49kD NADH-ubiquinone oxidoreductase NDUFS2 subunit Complex I-49kD NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial CI-49 complex I 49kDa subunit NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Qreductase)

Diseases related to NDUFS2

Discover more about diseases related to NDUFS2.

Nicotinamide Adenine Dinucleotide Coenzyme Q Reductase Deficiency
Leigh Disease
Cardiomyopathies
Parkinson Disease
Mitochondrial Diseases
Mitochondrial Encephalomyopathies
Acidosis
Nerve Degeneration
Obesity
Acidosis, Lactic
Optic Atrophy
Sclerosis
Leukoencephalopathy, Progressive Multifocal
Inborn Errors Of Metabolism
Weakness
Neurodegenerative Disorders
Leukoencephalopathies
Malignant Neoplasms

Pathways for NDUFS2

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Oxidative Phosphorylation
Translation
Transport
Cell Proliferation
Electron Transport
Aging
Proteolysis
Neurogenesis
Pigmentation
Thermotaxis
Phototaxis
Localization
Gliogenesis
Cell Death
Pathogenesis
Glycolysis

Research Areas for NDUFS2

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Core ESC-Like Genes
Stem Cell Markers

PTMs for NDUFS2

Learn more about PTMs related to NDUFS2.

Phosphorylation
Oxidation
Nitration

Bioinformatics Tool for NDUFS2

Discover related pathways, diseases and genes to NDUFS2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.