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The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer ofelectrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the innermitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of themitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrialcomplex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq)
