Nardilysin Products

Description

NRD1, also known as Nardilysin, has 2 isoforms, a 1,150 amino acid isoform1 that is 132 kDa and a 1,218 amino acid isoform2 that is 139 kDa, primarily found in adult heart, skeletal muscle, and testis, it is a member of the peptidase M16 family, and slices peptide substrates at the N-terminus of arginine residues in dibasic moieties. Disease research is being performed in relation to NRD1 and differentiating neuroblastoma, Down syndrome, Alzheimer's disease, neuroblastoma, prostatitis, neuronitis, and alcoholism. Interactions with NRD1 protein have been shown to involve TP53, HBEGF, CALCA, MYC, FBXW11, and more than 50 other proteins in proteolysis, neuromuscular junction development, cell proliferation, cell migration, and positive regulation of membrane protein ectodomain proteolysis processes.

Bioinformatics

Uniprot	NP_002516 Human O43847 Human
Product By Gene ID	4898
Alternate Names	N-arginine dibasic convertase EC 3.4.24 NRD-C nardilysin hNRD2 EC 3.4.24.61 hNRD1 NRD convertase nardilysin (N-arginine dibasic convertase)

Diseases related to Nardilysin

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Neoplasms
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Carcinoma
Carcinogenesis
Carcinoma In Situ
Malignant Neoplasms
Nervousness
Noninfiltrating Intraductal Carcinoma
Mammary Neoplasms
Cell Invasion
Vaccinia
Cognition Disorders
Virus Diseases
Alcohol-related Disorders
Tetraploidy

Pathways for Nardilysin

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Rna Processing
Localization
Sporulation
Rna Surveillance
Translation
Mating
Response To Nutrient
Meiosis
Conjugation
Cell Growth
Rna 3'-end Processing
Myelination
Cytokinesis
Response To Heparin
Mrna Transcription
Telomere Maintenance
Histone Acetylation
Histone Methylation
Secretory Pathway
Translational Readthrough

Research Areas for Nardilysin

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Neuroscience

PTMs for Nardilysin

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Phosphorylation
Cleavage
Dephosphorylation
Methylation
Biotinylation
Acetylation

Bioinformatics Tool for Nardilysin

Discover related pathways, diseases and genes to Nardilysin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.