Nardilysin Products

Description

NRD1, also known as Nardilysin, has 2 isoforms, a 1,150 amino acid isoform1 that is 132 kDa and a 1,218 amino acid isoform2 that is 139 kDa, primarily found in adult heart, skeletal muscle, and testis, it is a member of the peptidase M16 family, and slices peptide substrates at the N-terminus of arginine residues in dibasic moieties. Disease research is being performed in relation to NRD1 and differentiating neuroblastoma, Down syndrome, Alzheimer's disease, neuroblastoma, prostatitis, neuronitis, and alcoholism. Interactions with NRD1 protein have been shown to involve TP53, HBEGF, CALCA, MYC, FBXW11, and more than 50 other proteins in proteolysis, neuromuscular junction development, cell proliferation, cell migration, and positive regulation of membrane protein ectodomain proteolysis processes.

Bioinformatics

Uniprot	NP_002516 Human O43847 Human
Product By Gene ID	4898
Alternate Names	EC 3.4.24 EC 3.4.24.61 hNRD1 hNRD2 nardilysin (N-arginine dibasic convertase) nardilysin N-arginine dibasic convertase NRD convertase NRD-C

Research Areas for Nardilysin

Find related products by research area and learn more about each of the different research areas below.

Neuroscience